The etiology of Androgenetic Alopecia is multifactorial and polygenic. Androgen metabolism and receptors play a particularly important role. The action of dihydrotestosterone (DHT) and enzymes (5a reductase – I and II), which play an important role in the onset of the disease, has also been confirmed.

Hair loss (or thinning) differs between men and women, as it has a different clinical picture and hair loss distribution patterns are different. Early diagnosis and initiation of properly parameterized, and individualized treatment, with laboratory testing, detection and treatment of diseases such as thyroid disease, prevent and limit the fast progression of Androgenetic Alopecia (AGA).

AGA is due to the effect of androgens on genetically predisposed hair follicles. The Caucasian race has the highest frequency compared to other races. The severity and frequency increase over the years. At the age of 70, 80% of men and 45% of women have AGA.

A large number of children suffer from Adolescent onset AGA (AO-AGA) that is a special subtype of early onset AGA that requires special attention. The mean age of Adolescent onset AGA (AO-AGA) is 14 years in boys and 15 years in girls.

From adolescence onwards, androgens interact in the genetically predisposed and sensitive androgen hair follicles, causing a sequence of events that gradually causes the miniaturization of the hair follicles. The effect of androgens also causes a change in the hair cycle and progressive thinning and hair loss.

The distribution of androgen receptors and enzymes involved in the androgen metabolism (5-α Reductase Type I and II, aromatase and 17β-hydroxysteroid-dehydrogenase) in different areas of the scalp affects the pattern and severity of AGA. The levels of androgen receptors (responsible for the cellular action of androgens) are different in the frontal from the occipital region, with 1.5 times higher levels in the frontal region than in the occipital region.

The balance of enzymes, of androgen-converting in the target-organs is crucial for the metabolism of hormones with different androgenic potency. The enzyme 5-α Reductase (5AR) is responsible for converting testosterone (T) to dihydrotestosterone (DHT). (5-α Reductase, 3 times more in the frontal than in the occipital region).

In Athens South Dermatology Clinic, diagnosis and treatment are always performed only by the experienced and specialized Dermatologist Dr. Nektarios Lagaras (MD).

1. Step One – Digital Trichoscopy

The Digital Trichorizogram by the FotoFinder Trichoscale is useful to differentially diagnose other causes of hair loss and hair thinning as well as for assessing the development and to evaluate the treatment.

-It is painless in contrast to the traditional trichorizogram and without hair loss.
-It calculates the number, density and the phase of hair growth cycle (anagen, catagen and telogen)
-It provides an accurate custom PDF report as well as archiving and printing of the results.

​​4. Step Four -Θεραπεία (PRP) Autologous PRP Treatment with the Automatic Multiple Injection System HYCOOX injector

The pioneering, first and only in Greece, automatic system HYCOOX Multi Suction Auto Injector is the latest achievement of technology in the field of automatic multiple injection for the scalp.

In contrast to traditional techniques (Syringes, Pistols, Pens).

-It is completely painless.
-It is accurate in the amount of plasma injected into the scalp area.
-There are no leaks.
-It is Precise in the depth of the skin where the plasma should be injected.
-It enables a completely safe and fast Treatment.
-After double centrifugation, the precious plasma which contains proteins with Growth and Regenerative properties, with the necessary addition of special activators is injected into the scalp, achieving strengthening, utilizing the regenerative mechanisms of our own body, after restoring the function of the hair follicleshaving as a result the regrowth of new hairs but also the maintenance of the result for a lifetime.